Cerebral palsy is a disorder of movement caused by injury or abnormal
development in the brain, most often before birth or one month after birth.
Clinical symptoms of cerebral palsy mainly include abnormal posture, dystonia,
myasthenia, involuntary movement and ataxia, usually companied with disorder in
feeling, cognition, communication, action and secondary skeletal muscle
abnormality.
Pediatric cerebral palsy is a severe disabling disease happening in
childhood. Its incidence is around 1.5‰-5‰, taking the lead of pediatric
neurology and genetic counseling. Cerebral palsy directly affects Children’s
whole lives, causing severe disorders to their life and heavy burden to their
families. Therefore, finding an effective treatment has become the most
concerned thing of patients’ family members.
Stem Cell Transplations for Cerebral Palsy In China Hospital
Stem cells are known as “multifunctional cells” by medical circles for its
capacity of constant proliferation and differentiation. In certain condition,
they can differentiate into specialized cells with different functions and form
various tissues and organs. That is why they are used in treating diseases.
Clinically used stem cells need to go through a professional process, which
includes stem cell collection, separation and purification, before they are
cultured into specialized cells demanded in the treatment. After that, they were
transfused to the patient through intravenous injection or intervention. Due to
the self-duplication and differentiation capacity of stem cells, they can form
massive new cells to replace the injured cells. Stem cell transplantation is a
biological cell therapy, which does not cause side effect to patients.
Treatment principle of stem cell transplantation in treating cerebral palsy:
neurons differentiated by transplanted neural stem cells can replace and make up
the injured neurons and promote the differentiation of neural stem cells in the
patient’s brain tissues, so as to recover the normal growth and development of
brain nerve, repair the brain function and improve patient’s life quality.
Autologous means “self-derived”. MNCs is the abbreviation of "Mono Nuclear
Cells", which are isolated from bone marrow or mobilized peripheral blood (which
is collected from the patients' own blood).The MNCs contain several kinds of
cells, including: EPCs (endothelial progenitor cells), MSCs (mesenchymal cells),
MAPCs (multipotent adult progenitor cells), MIAMI cells(marrow-isolated adult
multi-lineage inducible cells), VSELs (very small embryonic-like cells), HSC
(hematopoietic cells) and etc.
Allogeneic cells are taken from different individuals of the same species.
Allogeneic cells at Puhua International Hospital are taken from the new-born
babies'umbilical cord blood.
In this way, the injected cells will move along the cerebrospinal fluid and
some of them can arrive at the injured part.
cells injected via IV approach will circulate around the whole body. In this
way, patient’s general condition can be improved.
Rehabilitation
As an integral part of cell therapy, the rehabilitations include daily
physiotherapy and occupational therapy sessions and complementary Traditional
Chinese Medicine treatment.These comprehensive rehabilitation therapies can help
improve patient's body functions, congnition etc.
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