What is Motor Neurone Disease
Motor neurone disease (MND) is the name given to a group of diseases in which
the nerve cells - neurones - controlling the muscles that enable us to move,
speak, breathe and swallow; undergo degeneration and die.
Motor function is controlled by upper motor neurones (UMN) in the brain that
descend to the spinal cord; these neurones activate anterior horn cells - lower
motor neurones (LMN). The LMN exit the spinal cord and directly activate
muscles. With no nerves to activate them, muscles gradually weaken and waste.
The patterns of weakness vary from person to person.
Motor neurone disease occurs at similar rates in most countries of the world.
It is estimated that there are presently around 400,000 people worldwide
diagnosed with MND and about 1900 people with MND in Australia. Slightly more
men than women are diagnosed with MND, most commonly in the 50 to 60 year age
group. However, MND may be diagnosed in adults at any age.
What causes Motor Neurone Disease
The causes of motor neurone disease are not yet known, but ongoing research
throughout the world is looking for causes.
There are many theories, including exposure to environmental toxins and
chemicals, infection by viral agents, immune mediated damage, premature ageing
of motor neurones, and loss of growth factors required to maintain motor neurone
survival and genetic susceptibility.
Most cases of MND occur spontaneously. These are said to be sporadic -
meaning occurring in scattered or isolated instances without clearly
identifiable causes. However, familial (hereditary) MND accounts for about ten
per cent of cases.
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