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Monday, November 2, 2015
Causes of Cerebral Palsy
Cerebral palsy is due to damage occurring to the developing brain. This damage can occur during pregnancy, delivery, the first month of life, or less commonly in early childhood. Structural problems in the brain are seen in 80% of cases, most commonly within the white matter. More than three quarters of cases are believed to result from issues that occur during pregnancy.[
While in certain cases there is no identifiable cause, typical causes include problems in intrauterine development (e.g. exposure to radiation, infection, fetal growth restriction), hypoxia of the brain (thrombotic events, placental conditions), birth trauma during labor and delivery, and complications around birth or during childhood.
Causes of Cerebral palsy such as :
Preterm birth
Between 40% and 50% of all children who develop cerebral palsy were born prematurely. Most of these cases (75-90%) are believed to be due to issues that occur around the time of birth, often just after birth. Multiple-birth infants are also more likely than single-birth infants to have CP. They are also more likely to be born with a low birth weight.
In those who are born with a weight between 1 kg and 1.5 kg CP occurs in 6%.Among those born before 28 weeks of gestation it occurs in 11%. Genetic factors are believed to play an important role in prematurity and cerebral palsy generally. While in those who are born between 34 and 37 weeks the risk is 0.4% (three times normal).
Term infants
In babies that are born at term risk factors include: problems with the placenta, birth defects, low birthweight, breathing meconium into the lungs, a delivery requiring either the use of instruments or an emergency Caesarean section, birth asphyxia, seizures just after birth, respiratory distress syndrome, low blood sugar, and infections in the baby.
As of 2013 it was unclear how much of a role birth asphyxia plays as a cause. It is believed, however, that only a small number of cases are caused by lack of oxygen during birth. It is unclear if the size of the placenta plays a role.As of 2015 it is evident that in advantaged countries, most cases of cerebral palsy in term or near-term neonates have explanations other than asphyxia.
Genetics
About 2% of all CP cases are inherited, with glutamate decarboxylase-1 being one of the possible enzymes involved. Most inherited cases are autosomal recessive, meaning both parents must be carriers for the disorder in order to have a child with the disorder.
Early childhood
After birth, other causes include toxins, severe jaundice, lead poisoning, physical brain injury, stroke, shaken baby syndrome, incidents involving hypoxia to the brain (such as near drowning), and encephalitis or meningitis. The three most common causes of asphyxia in the young child are: choking on foreign objects such as toys and pieces of food, poisoning, and near drowning.
Other
Infections in the mother, even infections that are not easily detected, may triple the risk of the child developing the disorder.Infections of the fetal membranes known as chorioamnionitis increases the risk.
Intrauterine and neonatal insults (many of which are infectious in nature) increase the risk.
It has been hypothesised that some cases of cerebral palsy are caused by the death in very early pregnancy of an identical twin.
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